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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65df52b28d590d451d99c9b16d11fc963ee25c6b67102f79b73e2c4ca721c10a' 
  AND token = 'D8sj2MKzfL6jcVb9vZ37V6rGhv7jmmEMtnRgwB1Inpc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}