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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ce966777cef03b2fe6e22066404ef87a56e65c4b02a0bc64dc8da6d37af50307' 
  AND token = 'cq4Mnjy3nL1o8npZopV5cI+NCKeuLvB9iaL6Y9J0hQM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}