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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0b818b411455ded27184e0b6c24bd65f952aeaf7f6021dd988ffe397de3d1c43' 
  AND token = 'POYKvyJRUl79XPMRnFfkrialQ5drHk5GweiM6VbwaV4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}