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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '12506d0f8a84e18f6f0b384c0a6f107b3aac8d6ac5d226230a27b14929caa3ba' 
  AND token = 'iuOIBI+2kxkLlaxaFsVaEFHdLmu4RuhQcZuyM+rI8qs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}