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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '09c2a82357a1dc2f9ee3b8e813d3f41f9da87af11ccad0a0e020405f19c40168' 
  AND token = '/4VPzM9FO46EYMYvV0lmVKBtcJTjpFBC+TDlXoPw4Is=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}