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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '421941dda6097b3f89bbb731de62759272ddc973d3510d443d9261b9f5edbe8f' 
  AND token = '0eKEkdkCi+4zJlT/+NVGdLs3GnLQgI8bW2Kgn1s4iNE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}