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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8aed7146695683f36e6f863b52fceedd4d8289be0c2b88e8c13d54d1f4dac36b' 
  AND token = 'bRtMJQBvlfl94Y8HzO39jA8CdaCXhPdfTAf9Nt5yJKQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}