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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '529e7d43353e407e4b092c9ac9a64c07043e9cfee5f4bb81dc2c878a112e52b9' 
  AND token = '6M/4rxVFkUrZtaqKDTzaFfTyNew3hKOLAvM60pG/uCw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}