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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43352fd9f3beda8cebfe89cc45560407c20172677fc2b0c5ee2e7855bad8b542' 
  AND token = 'GIGYS36fkdZ5+ZjhzDyLJze3q8pOy3WA/R6d85MUxdU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}