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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '53d53e8343061b55cf66b841d770b78ed0e81e4942cfe7a696595a3902280409' 
  AND token = 'oIGQlq6qyCAxnS78KPMmNfxN2qqudtRz3/adZdj6XOE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}