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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '181a782267e5b1c1f66fff51ccc6b7da840e41c37b51dc32f568f9a431a418e6' 
  AND token = 'fDqdd6cDHOspw+fpaW/SHmgmDsvOAGxq7e4m1a+lJJY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}