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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ae453f75e4e6f8dd888f1a094eb4240afd58226982b74df5f53a4ef047a40166' 
  AND token = 'O7ZI3FtwBPhLNlyNcm1SiuBwSbyY4Vl8NaYGmoWxAu4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}