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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd0d3d2b133074992f7daf5981260d169f5653bd1bc2aacc7362a6e0066cff282' 
  AND token = 'ZxUwTbK2E6HCOsQ8bCBRZdrRtb4/EOkRqUCvSbpU5gY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}