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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '626be439302be23a6332326b5682320dbbc465fe3d3fc436181e251b639bafda' 
  AND token = 'xN/InzpOKG5o4Af6eEb6ev1xA4kzkeaBlsnExnX1U5Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}