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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21caa00b86edae558e646def1ff0a3d9e22a5b5d0236a84c32a22b03e52e9c49' 
  AND token = 'cAt91fmvwCB6lNJFIQlqHYQdVMOPWOS8sokJ44n1ul4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}