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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4d3ec68f61d1013dfb134072d0863bbe2c75b02d2a1bfc07b1a9375a9c30c822' 
  AND token = 'dPc1tmMSGO5fig//rsth9J+oHDIfUIFvvMAFn2PSto4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}