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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a1e74a1822053ce7c2c32dcf8a2d90a245d56edc13dcb98e2a1e3022796af4c5' 
  AND token = '5cFqe96Ee/XY/l+zfMHOeeNz7cuKQb8NGPU7r9/CmjA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}