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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'efdfbb8c165b49d170b82088df80042ea8181f0a28c9461a935849be506762c1' 
  AND token = 'wRkXYTEs/s16T0SwsXSz7m0PUJYvk3AT9leLuRkMa+0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}