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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e6a4300dff90b71e006f200a60954b4f61b3c41c6a785cceef2c43767e6bfc12' 
  AND token = 'af0Bc7nuKsq5mqyFq4x3t61Vllb9vdapRP3+RAbP4Vc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}