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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c8dc65f85cdf485be154d9d4ebd7ccda009c71526ce9b85fec99664030d38cf2' 
  AND token = 'HUcgUQ8LBBzs5EcHM+CAfxBVIXl2wGk1pl+ePUMwgJI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}