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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '980ac21ffeb55b9d7f4e01f1cd6d599cc4ddf45625fd417543ee628a44f54746' 
  AND token = '+om0f2OG8bCm5W9m70drHxWtgayn2WXwvqLMSyxaqVM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}