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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e78803f5a65a98cc6cd4c700343609f08732d4d1de7f8de7562042b6b42205ec' 
  AND token = 'CyiwiV25cTr4DzDzqMprfhe474kwbDG1uDj1zlcrugA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}