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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8c66f09d1fafe1ea0fb73c27cee88dad1eb52778fb06c3f67d6ac171a634b312' 
  AND token = 'nPne0v7TpekYXOOCgvSjdq6fPnEalCsHDy9jRQs+eCo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}