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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b3f1c3e6019dcf1b22204bc70e24edccbf8b71083a6c5a2873e836a2b181935e' 
  AND token = 'tdlGnECUT0eMwhHLs8DmHv6u9dwb2Q+9SQ5++S9RNpI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}