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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f2e4f794ee7d2dd91014b2b68252bcf83ac04a395f1ed6de95328fa67d3d0770' 
  AND token = '9h0t0rZHZQYR6qn0TC+ZQTvzGvhiOVP8ZndDOsQ175c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}