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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '18e81caea1ed63c7bef0d616ea4bf712cc35700c0ba3369871644b18b868e00a' 
  AND token = '8/CBFeaBn0hSIm6tW7TsZlM2kX4mxjvIfp4M0rPNy0A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}