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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9d455216b303660444c0e2b80ba8f1ca8ce6259a584a4887bada1148434c794d' 
  AND token = 'Y1dyOMzLqeQEtzkJi5aCgGqOthFfScHRuTAri+Rh0X0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}