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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c9373a4e5ff53e4a38293152296a32cb5f14a809aea1e0ed10741c711e1b9ae8' 
  AND token = 'yyrZbvE17KzCUbqCGpOeFNMSRGrjfccZ/tIXxTXUDlc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}