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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd0490d2b7df99e3724f9355132d7c66733c847fc998841863d6653c2947c1445' 
  AND token = '+lwisWZMlQja9aRRsoupg0IFPi+Mh4mIV80Wm049hbE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}