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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '489d43a7f338abb5aa2b2988bb09ea5f927afee660c8dd070be00fec5b8aa94f' 
  AND token = 'gONQ/eZeAgCs5+S3HDk8nyVYnM4PmiPPq/vyGZm31hE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}