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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4d2c268e01fd6b64b74e51c2c4b256b4cfbb9490824f6e35bfda0bbb9b7b9af4' 
  AND token = 'tUyi7d7+wZMGdCBxlwnbGB3CGvtsAnsC2jzUsWRe2yY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}