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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '222ba81fdc141cb57543743efeef751be1e29ca5e6307c1fde3c82f32e89f65f' 
  AND token = 'mYEG6QhtPyFm5aqCuniOKH3faS+QwXS8UIlOwMztoFM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}