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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c2758fc1e1e5871a0137619447e44b8d1bd14ffc5e44dc53be29ee1266a48d29' 
  AND token = 'qa1BDVyPT8dMwlEqYVGWuiBQGvPwBmD6Lm1QTH0bnjA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}