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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ccc37f34befe577a9b476465c667e1bc1fde584bdcecd312c47fdfd2e8f10fcd' 
  AND token = 'DI9SSjIAiTbDnDiDb9qEBYUmyRy25KD+1WOSbtn7Xf0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}