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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4dfe73b7b6e7ce1321d26d40a4086fdb97a4221b272b21f7e971914f080d12af' 
  AND token = '4EMC7/hleef88C1A8PZy9sWYNEYmomkF4Vyj5z1CHkI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}