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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '489cb80209e91003edf8fb14aaa66ac8a06cb4f638db7d807293ead950664331' 
  AND token = 'JKt7UYA1QkJrSJgMqCfAAZUiairFzo7rJzeXi0QgezU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}