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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a6f3ffdbd498cc0137a6c9b6a67747072a7188ec5178380fe083556a93311e35' 
  AND token = 'acNRumcuRCHiQOtM/hQ3v6gm2wMFeYhxxnCD0yEHv8g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}