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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8accb307cb8ec7ff3db3f879f4d2507a6f7b2f94a6ddb38b470f64a7b9070c51' 
  AND token = 'tXsynFuuPtLiUCeEBB5F5bLMWrsk7kcrwIgIJhA3q0A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}