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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6e2d156dbd4c87d623fca203210b8617961dff096975d8eaa889c754dd67f6f1' 
  AND token = 'PVZym08T3PsME6NbayYiGIW4NO1MTXv3SIgWllH7fgY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}