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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'fc0cfe753177264173cd1b9a7df192a83b0be066b039edd91cc55083732cbcf6' 
  AND token = '/LtkqsVFVTPBRUB9y0UvC1WDDBv5Tgbrp2Ln80XZXEg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}