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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8e681ca0151a42a3e0928e28c36398f774356ed14eddf7c4f0e03dfb00149cc8' 
  AND token = 'P2aPtlaJsifcsxAOQxMEYqjWSq2Z56Fje6i8KbZIYcY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}