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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0b243fbffed5d24b8ddcc70f4d18559d047bbef9b06e8bd18b9b982f72046422' 
  AND token = 'HTLV4UeYMetPx9NJugJMGbbImlgqbrCYR3uBWkZLqvg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}