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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'defb2900ed0a8edca0ec6b1c4d12065e10c28e4f2d8738a3440b7340d00e7c19' 
  AND token = 'PxCqHKTomWE+znG8FvjOPHD4xsw58MQcpfa3CAksyCM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}