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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5a4b2160ea72e56ae6c15e00ea4229b75a20a5c0e49394177e503708122da382' 
  AND token = '4KaoMENFtMGTB3aLGGwsXnQkOdG3+7vqDVICLzlpeEo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}