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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6c49d4f0c891327650db10596e8cfd53fbe3ecaf5c8df8ff5a31f59624696d15' 
  AND token = 'l4KT39N7Z7E9u2eZNe+oYmGMwC7ziEFZ1SCXTYTLJ/4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}