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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8d4216a7a6bc8038ced82df01b09e33872395b1ac4d3ad7ba2d65813787747ec' 
  AND token = 'Qx7kYeDeQFKTpjaVaADnBnk5i/4OgAM+5MeosAKw4zE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}