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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '44396f4c966dafeb1b1becb82c44eba0e25cd1a025148b2ec1231da310a21067' 
  AND token = 'ph5c0gbfMFE4SrWYdO1CEOjbiYzVMXn7oOtEc2ZmoP4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}