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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c45c230d8d9d918eb74fb6a7a00e66cef974850f15645b3740dfadcd3dc69cf5' 
  AND token = 'WULwq9E6aPS4KkRkSLhKxoiSW6WK20qha58WfVaWtVA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}