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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45d0e66bc44be486de34f5d4baed4758b28516c3c3d5fb2e6732ba48b83ddf94' 
  AND token = 'q+KMS9IAsW/BHl71L65/SbLb+/tIVmaRgCvcWjU4AuQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}