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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '74d980566ef94b66b6af8e40e9c80eb267008fe8684851d4b88e176736c45f7f' 
  AND token = 'TzR2PYZ7tyWAGUpe84N/u2EVh9v3SG0I1ZZ3MtBRP2E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}